A new survey shows high usage rates of cannabinoids like CBD for multiple sclerosis, but most patients are figuring out these new products on their own. CBD Oil and MS: Is Cannabis Oil a Miracle for Multiple Sclerosis? CBD — short for cannabidiol — has a long list of well-documented health benefits. People use CBD oil to improve general Can CBD help with your MS symptoms? Learn more about the research, how to take it, side effects, and more.
More People with MS Turning to Cannabis for Help with Pain, Sleep
A new survey shows high usage rates of cannabinoids like CBD for multiple sclerosis, but most patients are figuring out these new products on their own.
More than 40% of those with multiple sclerosis said they’ve used cannabis products in the past year, according to recently published results from a national survey on pain in people with MS.
And those who turned to products with some combination of compounds derived from the cannabis plant (CBD, or cannabidiol, and THC, or tetrahydrocannabinol) were most likely to try them for help with chronic pain and sleep—two symptoms that are common and often go together in this chronic neurological disease.
It represents an increase from previous studies of CBD/THC use in MS, as more states legalize marijuana use recreationally and/or medically. However, there’s a wide gap between the proportion of people with MS who have used a cannabinoid in the past year (42%) and the proportion who have spoken with their physician about it (only 18%). Furthermore, fewer than 1% of cannabinoid users received information from their provider about the type of cannabinoid product recommended for their symptoms.
“Reasons for the disconnect between respondent use and provider guidance in our sample requires further study, but reinforces a longstanding concern that research focused on the use of cannabinoids for MS symptoms has not caught up with consumer use of these products,” says lead author Tiffany Braley, M.D., M.S., an associate professor of neurology and an MS specialist at Michigan Medicine.
The study included survey responses from more than 1,000 people with a diagnosis of multiple sclerosis from across the nation.
When it comes to selecting a cannabinoid product, survey respondents who had a preference tended to use CBD products, which don’t have the same psychoactive effects of THC and tend to be easy to find online or in stores in many different forms.
Senior author Anna Kratz, Ph.D., an associate professor in the department of Physical Medicine & Rehabilitation, said “patients are looking for guidance from their providers to make informed choices about whether cannabis compounds should be used at all, and if so, which formulations would be most beneficial.”
However, providers still don’t have a lot of good evidence to help them advise patients who plan to explore a cannabinoid for their chronic MS symptoms. It’s frustrating, Braley says, because symptoms like chronic pain and some sleep disturbances in MS can be challenging to treat with existing options, and new, safe, more personalized approaches would be welcomed. “However, provider guidance for patients must be informed by research focused on the benefits and harms of both CBD and THC, and potential mechanisms that underlie the effects of cannabinoids on MS symptoms.” she says.
Braley adds many publications about cannabis in MS, including this one, have had populations that skew female-identifying and white, highlighting a need for more diverse perspectives from racial and ethnic minorities that have been historically underrepresented in MS research.
Paper cited: ” Cannabinoid use among Americans with MS: Current trends and gaps in knowledge.” Multiple Sclerosis Journal – Experimental, Translational and Clinical. DOI: 10.1177/2055217320959816
CBD Oil and MS: Is Cannabis Oil a Miracle for Multiple Sclerosis?
CBD — short for cannabidiol — has a long list of well-documented health benefits. People use CBD oil to improve general well-being and to alleviate a wide range of symptoms, from anxiety to pain, inflammation, and neurological problems.
However, some areas where CBD could potentially help, are yet to be thoroughly examined.
Such is the case of using CBD oil for multiple sclerosis (MS).
Many MS patients are successfully taking cannabidiol, claiming it helps with their symptoms and repairs damaged nerves.
Current research shows that extracts like CBD oil can be effective in reducing pain and spasms in MS patients.
But can CBD oil actually treat multiple sclerosis?
Unfortunately, the research is still inconclusive. In this article, we’ll cover the most important aspects of using CBD oil for MS — including the benefits, different consumption methods, and possible side effects.
What is Multiple Sclerosis?
Multiple Sclerosis is a self-aggressive disease where the body’s immune system attacks the central nervous system (CNS). Scientists are still trying to discover the exact cause of MS; however, the general consensus is that this disease may be triggered by a combination of genetic and environmental factors.
Currently, about 2.3 million people in the US suffer from MS. The majority of diagnosed patients are between their 20s and 50s — it’s unclear why some people have this condition while others don’t.
Multiple Sclerosis damages the protective layer around nerve fibers (myelin). When the CNS notices the patches of scars left behind by an aggressive immune system, it starts to send false signals to the brain — leading to an array of symptoms.
In some people, these symptoms are relatively mild like extensive fatigue, while other cases involve severe pain, involuntary muscle cramps, impaired memory and focus, and vision problems.
When left untreated, multiple sclerosis may result in partial or complete paralysis.
Types of Multiple Sclerosis
There are 4 main forms of multiple sclerosis based on the type and severity of symptoms:
This is the most prevalent type of MS and affects about 85% of patients diagnosed with MS.
People with RRMS suffer from periodical fare-ups that exacerbate their symptoms, followed by silent periods where the patient remains symptom-free until the next flare-up.
For SPMS sufferers, symptoms deteriorate over time but without flare-ups. In most cases, RRMS transforms into SPMS.
A less common form of MS, primary-progressive multiple sclerosis affects about 10% of all MS patients.
This form of the disease is marked by worsening symptoms from the beginning, without flare-ups or remissions typical to other types of MS.
This is the rarest form of MS and occurs in about 5% of MS sufferers. The symptoms of PRMS worsen steadily over time, with flare-ups and acute relapses but without remission periods.
What is CBD Oil?
CBD oil is a concentrated CBD extract made from cannabis plants — both hemp and marijuana.
CBD is a cannabinoid — a naturally occurring phytochemical — and the second-most recognized active ingredient of cannabis.
Unlike the most popular cannabinoid, delta-9-tetrahydrocannabinol (THC), CBD is non-psychoactive and thus won’t get you high. This makes CBD legal in most countries across the world.
The lack of psychoactive effects doesn’t make it an inferior cannabinoid. On the contrary, CBD has a long list of well-documented health benefits with only a few mild side effects. Cannabis advocates argue that CBD can help with virtually any condition deriving from a compromised endocannabinoid system (ECS) — the prime neurochemical network in our bodies.
Most CBD stuff sold online and in local dispensaries comes from hemp plants, which takes us to the next question.
How is CBD Hemp Oil Different from Medical Marijuana?
The main difference between CBD from hemp and medical marijuana is the aforementioned THC content.
Hemp plants are high in CBD and very low in THC. The THC content of hemp plants is usually below 0.3%, which isn’t enough to produce any psychoactive effects.
On the other hand, marijuana has high THC levels and doesn’t offer much CBD. However, some strains are specifically bred to achieve higher CBD levels at the cost of some THC.
Still, you won’t buy marijuana products in your local head shop or health store as marijuana remains a controlled substance according to federal law. You can buy medical marijuana if you live in a state that runs a medical marijuana program.
CBD oil from hemp is legal in all 50 states. You can find it in cannabis dispensaries, head shops, and online stores. You don’t need a doctor’s prescription to try CBD oil for multiple sclerosis.
Different Ways to Take CBD Oil for Multiple Sclerosis
If you’re considering trying CBD oil for your MS symptoms, it is available in the form of oil drops, tinctures, sprays, capsules, and edibles, which can be ingested, as well as vape products and creams for topical use.
Can CBD Oil Help With Multiple Sclerosis?
Dr. Ben Thrower, a physician at the Shepherd Center in Atlanta, GA, is very optimistic about using CBD oil for multiple sclerosis, but at the same time, he underlines the importance of THC in the treatment.
“Many of our MS patients have used hemp-based CBD products with 0.3 percent THC or less (…) For the management of spasticity/spasms or burning pain (central neuropathic pain), I have found that most patients need higher THC concentrations.”
THC is a well-known pain reliever — this may explain the need for higher levels of THC in CBD products for treating MS symptoms.
However, Thrower points to CBD topicals as a potential solution for fighting localized pain in MS patients
“Some patients do find relief with Low-THC, CBD lotions applied topically,” said Thrower.
What Does the Research Say About Using CBD Oil for Multiple Sclerosis
In a 2009 study, researchers investigated previous reports from MS patients who used cannabis for their symptoms to find out whether a mix of CBD and THC may reduce spasticity associated with MS.
Each of the analyzed papers focused on testing THC and CBD in capsules and oral sprays. These products generally involved more THC than CBD, which resulted in a trend of reduced spasticity.
Researchers also concluded that THC/CBD solutions are well tolerated by patients and that the experienced side effects didn’t always stem from using cannabis alone.
In 2016, researchers were looking at how a pharmaceutical spray Sativex might reduce muscle spasms in MS sufferers.
Sativex is an oral solution made from CBD and THC in a 1:1 ratio. The spray was developed to reduce neuropathic pain, overactive bladder, spasticity, and other common symptoms of multiple sclerosis.
Researchers examined self-reported data from several hundred MS patients who were using the drug for one year. Results showed a 20% improvement in muscle spasticity for 70% of subjects and a 30% improvement in 28% of patients.
For about 39% of patients, the treatment was ineffective. Although those patients dropped out of the study, the results do provide evidence to support further research on cannabinoids for multiple sclerosis.
Finally, there’s a 2018 research review that analyzed existing studies to find indirect that CBD, along with other cannabinoids, can improve the mobility of MS patients.
The paper focused mostly on a high CBD to THC ratio as the potential reliever of muscle spasms and pain in MS patients. It also discussed how cannabis reduces inflammation, contributing to less fatigue in subjects.
Because CBD oil may be able to alleviate so many symptoms of multiple sclerosis — pain, spasticity, inflammation, and fatigue — it’s reasonable to assume that CBD can have a positive impact on mobility in MS patients.
What Are the Side Effects of Using CBD Oil for Multiple Sclerosis?
When it comes to unwanted reactions to CBD, Thrower said there are very few. They’re also uncommon and generally considered mild.
“I have found the side effect profile of these products to be less than some of the prescription medications,” he added. “CBD/THC products tend to be far less sedating than Baclofen or Tizanidine, which are [muscle relaxants] traditionally used for spasticity,” he added.
Most often, taking too much CBD oil results in a dry mouth, lowered blood pressure, and dizziness. In very rare cases, high doses of CBD oil can trigger diarrhea.
Key Takeaways: What You Need to Know About Using CBD Oil for MS
So, there you have it — everything we know about using CBD oil for MS so far.
Let’s summarize the article in a nutshell:
- CBD can be effective in reducing pain and spasms in multiple sclerosis patients
- However, CBD alone has limited potential for relieving MS.
- It appears that adding THC significantly improves the therapeutic properties of CBD
- Some people can have negative reactions to the psychoactive effects of THC, especially if their symptoms call for higher doses of medical cannabis oil.
- Moreover, equal ratios of CBD to THC may not work for certain people, as studies have shown.
- Full-spectrum cannabis extracts with higher ratios of CBD to THC may be able to relieve a wider range of symptoms and improve mobility in MS patients.
- Hemp-derived CBD topicals may be effective in reducing localized pain and inflammation during flare-ups.
I hope this article has helped you understand how cannabinoids work for specific MS symptoms. As always, make sure to contact your GP before taking any CBD product, especially if you’re already taking prescribed medications cannabidiol can interact with.
Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.
What to Know About CBD and MS
The FDA hasn’t approved CBD to treat multiple sclerosis, or MS. Studies are ongoing, but the evidence is mixed. Here’s what we know.
How It May Help
Experts think CBD affects your brain by attaching to certain receptors in the central nervous system. They change the way these receptors respond to stimulation. This may ease inflammation and help with your brain’s immune responses.
More research is needed, but scientists think CBD may help with these MS symptoms:
How to Take CBD
It comes in many forms. You can find CBD in:
- Certain foods or drinks (oral capsules, oral sprays, nose sprays, oils)
- Personal care products you rub on your skin
CBD oil is a common way to take it. You can put it under your tongue or add it to your food or drinks. You can also put it on your skin. Some research found sprays you put under your tongue might be best for MS.
CBD is considered a dietary supplement. The FDA doesn’t regulate supplements, so there’s no way to know if what you’re getting is safe and effective. Studies show many CBD products aren’t as pure as the label says. Some have ore or less CBD. Others may have some THC in them.
Experts say taking 300 milligrams a day by mouth for up to 6 months might be safe. Taking 1,500 milligrams per day by mouth for up to 1 month may be OK, too. People have used 2.5-milligram sprays under their tongue for up to 2 weeks.
What to Watch For
Possible side effects may include:
Eating foods that are high in fat can cause your body to absorb more CBD. This can lead to side effects. It could react with other medications you’re taking, such as blood thinners. Be sure to talk to your doctor before trying any form of CBD.
Harvard Medical School: “Cannabidiol (CBD) — what we know and what we don’t.”
National Institute on Drug Abuse: “What is marijuana?”
FDA: “FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD).”
MS Trust: “Sativex (nabiximols).”
Frontiers in Neurology: “Cannabidiol to Improve Mobility in People with Multiple Sclerosis.”
British Journal of Pharmacology: “The endocannabinoid system as a target for the treatment of neurodegenerative disease.”