Cannabidiol and Sports Performance: a Narrative Review of Relevant Evidence and Recommendations for Future Research Open Access This article is licensed under a Creative Commons Attribution 4.0 This plant compound found in marijuana may be able to help drive gains by wiping out pain and boosting recovery. Don’t know when to take CBD oil for workouts? Our team can help! Read on to find out now.
Cannabidiol and Sports Performance: a Narrative Review of Relevant Evidence and Recommendations for Future Research
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Cannabidiol (CBD) is a non-intoxicating cannabinoid derived from Cannabis sativa. CBD initially drew scientific interest due to its anticonvulsant properties but increasing evidence of other therapeutic effects has attracted the attention of additional clinical and non-clinical populations, including athletes. Unlike the intoxicating cannabinoid, Δ 9 -tetrahydrocannabinol (Δ 9 -THC), CBD is no longer prohibited by the World Anti-Doping Agency and appears to be safe and well-tolerated in humans. It has also become readily available in many countries with the introduction of over-the-counter “nutraceutical” products. The aim of this narrative review was to explore various physiological and psychological effects of CBD that may be relevant to the sport and/or exercise context and to identify key areas for future research. As direct studies of CBD and sports performance are is currently lacking, evidence for this narrative review was sourced from preclinical studies and a limited number of clinical trials in non-athlete populations. Preclinical studies have observed robust anti-inflammatory, neuroprotective and analgesic effects of CBD in animal models. Preliminary preclinical evidence also suggests that CBD may protect against gastrointestinal damage associated with inflammation and promote healing of traumatic skeletal injuries. However, further research is required to confirm these observations. Early stage clinical studies suggest that CBD may be anxiolytic in “stress-inducing” situations and in individuals with anxiety disorders. While some case reports indicate that CBD improves sleep, robust evidence is currently lacking. Cognitive function and thermoregulation appear to be unaffected by CBD while effects on food intake, metabolic function, cardiovascular function, and infection require further study. CBD may exert a number of physiological, biochemical, and psychological effects with the potential to benefit athletes. However, well controlled, studies in athlete populations are required before definitive conclusions can be reached regarding the utility of CBD in supporting athletic performance.
CBD has been reported to exert a number of physiological, biochemical, and psychological effects that have the potential to benefit athletes.
The available evidence is preliminary, at times inconsistent, and largely based on preclinical studies involving laboratory animals.
Rigorous, controlled investigations clarifying the utility of CBD in the sporting context are warranted.
Cannabis sativa contains numerous chemical compounds with potential bioactive effects, including at least 144 cannabinoids [56, 76]. The most studied of the cannabinoids are Δ 9 -tetrahydrocannabinol (Δ 9 -THC), renowned for its distinctive intoxicating effects [73, 123], and cannabidiol (CBD)—a non-intoxicating cannabinoid that is particularly enriched in industrial hemp cultivars grown for seed and fibre . CBD was first isolated in 1940 and initially considered to be biologically inactive, with no apparent therapeutic or “subjective” drug effects . However, in 1973, Carlini et al.  demonstrated anticonvulsant effects of CBD in a preclinical model, which were later mirrored in humans suffering from intractable epilepsy . A subsequent rise in research into CBD  has uncovered interactions with numerous molecular targets  and a range of potential therapeutic applications . Following successful phase 3 clinical trials [53, 54, 172], the oral CBD solution, Epidiolex®, has also recently gained Food and Drug Administration approval as a regulated prescription medication to treat certain forms of paediatric epilepsy.
Recently, interest in CBD has intensified among the general population as evidenced by an exponential rise in internet searches for ‘CBD’ in the United States (USA) . Some professional athletes (e.g. golfers, rugby players) also appear to be using CBD (e.g. ‘Team cbdMD’ https://www.cbdmd.com/), despite there being no published studies demonstrating beneficial effects on sport or exercise performance. In many jurisdictions, including the USA and Europe, access to regulated, prescription CBD (i.e. Epidiolex®) is limited to patients with intractable epilepsy. However, a wide range of low dose (e.g. 5–50 mg·d −1 ) CBD-containing “nutraceuticals” (primarily in oil or capsule form) have become readily available online and over-the-counter (e.g. pharmacies, health food stores) [20, 125]. This includes some varieties that are marketed specifically to recreational and elite athletes (e.g. cbdMD, fourfivecbd). The use of these products is likely to become even more widespread if the World Health Organization’s recommendation that CBD no longer be scheduled in the international drug control conventions is adopted by the United Nations member states .
Cannabis has been prohibited in all sports during competition since the World Anti-Doping Agency first assumed the responsibility of establishing and maintaining the list of prohibited substances in sport 15 years ago . In 2018, however, CBD was removed from the Prohibited List , presumably on the basis of mounting scientific evidence that the cannabinoid is safe and well-tolerated in humans [16, 169], even at very high doses (e.g. 1500 mg·day −1 or as an acute dose of 6000 mg) . While several recent reviews have described the impact of cannabis on athlete health and performance [99, 176, 188], the influence of CBD alone has yet to be addressed.
The aim of this narrative review was to explore evidence on the physiological, biochemical, and psychological effects of CBD that may be relevant to sport and/or exercise performance and to identify relevant areas for future research. Given the absence of studies directly investigating CBD and sports performance, this review draws primarily on preclinical studies involving laboratory animals and a limited number of clinical trials involving non-athlete populations.
Cannabidiol (CBD): Molecular Targets, Pharmacokinetics and Dosing
The distinctive intoxicating effects of Δ 9 -THC (as well as some of its therapeutic effects) involve the activation of CB1R (the cannabinoid type 1 receptor) . This ubiquitous receptor is expressed throughout the central nervous system, the peripheral nervous system, and in the cardiovascular system, gastrointestinal (GI) tract, skeletal musculature, liver, and reproductive organs . Unlike Δ 9 -THC, CBD is not an agonist of CB1R, although it may act as a negative allosteric modulator (NAM) at this site (i.e. decreasing the potency and/or efficacy of other ligands without activating the receptor itself) [92, 106]. Δ 9 -THC also acts as an agonist at CB2R (the cannabinoid type 2 receptor)  and there is emerging evidence of CBD functioning as a partial agonist at this site . CB2R is primarily located on immune system cells but is also expressed in the cardiovascular system, GI tract, bone, liver, adipose tissue, and reproductive organs . CBD may also influence the endocannabinoid system indirectly via the inhibition of fatty acid amide hydrolase (FAAH), a key enzyme involved in the degradation of the principle endocannabinoid signalling molecule, anandamide (AEA) [92, 110]. The inhibition of FAAH is predicted to lead to an increase in brain and plasma concentrations of AEA, which acts as a partial agonist at CB1R and CB2R, thereby increasing endocannabinoid tone [92, 110]. Increases in endocannabinoid tone may also occur as a result of CBD inhibiting AEA transport via effects on fatty acid-binding proteins (and this mechanism may have more relevance than FAAH inhibition in humans) .
CBD also interacts with many other non-endocannabinoid signalling systems . Briefly, at concentrations ≤ 10 μM, CBD has been reported to interact with the serotonin 1A [5-HT1A] receptor, the orphan G protein-coupled receptor 55, as well as the glycine, opioid, and peroxisome proliferator-activated receptors, various ion channels (e.g. the transient potential vanilloid receptor type 1 channel [TRPV1] and other transient potential vanilloid channels) and various enzymes (e.g. cyclooxygenase (COX)1 and COX2, cytochrome P450 enzymes) [11, 92] (see Ibeas et al.  for review). CBD also possesses antioxidant properties .
It is important to recognise that the molecular targets of CBD are still being established, with many of those identified in in vitro cellular assays still to be validated as occurring in vivo. As such, the functional relevance of many of these interactions remains to be established.
CBD is often consumed orally as oil; however, it can also be ingested in other forms (e.g. gel capsules, tinctures, beverages, and confectionery products) and applied topically [20, 125]. High concentration CBD “vape oils” (i.e. for use in e-cigarette devices) are also available in some countries, as are some CBD-dominant forms of cannabis (sometimes known as “light cannabis”) that can be smoked or vaporised [20, 125]. Pure, synthetic, crystalline CBD was also vaporised in a recent laboratory study .
Taylor et al.  recently conducted a comprehensive analysis of oral CBD oil pharmacokinetics in healthy participants. When administered as a single, oral dose (1500–6000 mg), the time to reach peak plasma concentrations (tmax) was ~4–5 h and the terminal half-life was ~14–17 h. Although tmax did not increase dose-dependently in this investigation , another study , involving a much lower oral dose of CBD (300 mg), did indicate a shorter tmax (i.e. ~2–3 h). Peak plasma concentrations (Cmax) were ~0.9–2.5 μM in Taylor et al. , but increased ~4.9-fold when CBD was administered with a high-fat meal (i.e. ~5.3 μM at 1500 mg dose) . Both studies observed a large amount of inter-individual variation in pharmacokinetic responses [19, 170].
The pharmacokinetics of inhaled CBD are yet to be well characterised. However, smoked “light cannabis” (with a lower Δ 9 -THC and higher CBD content than other varieties) has been reported to elicit high serum CBD concentrations at 30 min post-treatment (that decline over time) . A recent study in which participants vaporised 100 mg of CBD likewise observed high blood CBD concentrations 30 min post-treatment . As neither study collected blood samples within < 30 min of CBD administration, tmax and Cmax are unknown [146, 160].
CBD is metabolised by several cytochrome P [CYP] 450 enzymes (e.g. CYP3A4, CYP2C9, CYP2C19) which convert it to a number of primary and secondary metabolites (e.g. 7-OH-CBD, 6-OH-CBD, and 7-COOH-CBD) . Complex pharmacokinetic interactions may occur when CBD is co-administered with other drugs (e.g. Δ 9 -THC) and dietary constituents (e.g. caffeine) that also utilise these enzymes [6, 163].
Interspecies Dose Conversions
Given the number of preclinical studies involving animal models that will be discussed in this review, it is important to consider interspecies dose equivalence (Table (Table1). 1 ). The USA Food and Drug Administration  recommend the following approach to interspecies dose conversion:
Oral human equivalent CBD doses from mouse and rat intraperitoneal doses
|Mouse to Human CBD Dose Conversion||Rat to Human CBD Dose Conversion|
(mg·kg -1 , i.p.)
(mg·kg -1 , i.p.)
Each HED is based on a body mass of 60 kg and calculated as per the methods described in 2.3 Dose Conversions. The highest documented acute oral CBD dose in humans is 6000 mg; the highest documented chronic oral CBD dose in humans is 1500 mg . HED: Human Equivalent Dose; i.p.: Intraperitoneal; p.o.: Oral
Where HED is the human equivalent dose and Km is a correction factor estimated by dividing the average body mass (BM) of the species (60, 0.020 and 0.150 kg for 11 humans, mice and rats respectively) and by its surface area (see: Nair, et al.  for 12 further details).
Differences between systemic and oral dosing should also be considered . Intraperitoneal (i.p.) dosing is often used in animal studies and has been reported to elicit Cmax values ~7-fold higher than oral dosing in mice . Thus, an “oral equivalent dose” can be approximated by multiplying the i.p. dose by seven  (Table (Table1). 1 ). Intravenous (i.v.) dosing will produce even higher plasma CBD concentrations; however, the authors are not aware of any published data that would facilitate conversion between i.v. and oral dosing in rodents. Please note that these values are intended as a guide only and subject to limitations (e.g. interspecies differences in drug potency and receptor expression/configuration).
Cannabidiol (CBD) in Sport and Exercise Performance
Literature Search Methodology
The clinical and preclinical literature was reviewed to identify studies investigating the effects of CBD that might be relevant within a sport and/or exercise context. The online databases PubMed (MEDLINE), Web of Science (via Thomas Reuters), and Scopus were searched between April and October of 2019 using terms such as: ‘cannabinoid’ ‘cannabidiol’, ‘CBD’ and ‘cannabis’. This review focuses primarily on effects that have been demonstrated in vivo and generally avoids attempting to predict functional effects on the basis of target-oriented in vitro data, given the numerous molecular targets of CBD  and the fact that exercise itself induces complex biochemical changes. Nonetheless, some potential interactions are noted. As our intent was to summarise evidence on a range of potentially relevant topics, rather than provide a detailed assessment of the literature, the reader will be directed to more focused reviews, where appropriate. All doses described are oral and acute (single), unless otherwise stated.
Exercise-Induced Muscle Damage—Muscle Function, Soreness, and Injury
Exercise, particularly when strenuous, unfamiliar, and/or involving an eccentric component, can cause ultrastructural damage to skeletal muscle myofibrils and the surrounding extracellular matrix [36, 59]. This exercise-induced muscle damage (EIMD) impairs muscle function and initiates an inflammatory response . While inflammation is integral to EIMD repair, regeneration, and adaptation , excessive inflammation may contribute to prolonged muscle soreness and delayed functional recovery [7, 158].
CBD modulates inflammatory processes . In preclinical models of acute inflammation, CBD has been reported to attenuate immune cell accumulation (e.g. neutrophils, lymphocytes macrophages) [102, 130, 149, 186], stimulate production of anti-inflammatory cytokines (e.g. interleukin (IL)-4, IL-10) [190, 191, 23] and inhibit production of pro-inflammatory cytokines (e.g. IL-1β, IL-6, IL-8, tumour necrosis factor (TNF)-α) [10, 50, 55, 62, 63, 113, 130, 149, 154, 186] and reactive oxygen species [62, 130, 186]. Models demonstrating such effects have included lung injury induced by chemical treatment  and hypoxic–ischemia (HI) ; liver injury induced by ischemia-reperfusion [63, 130] and alcohol feeding ; myocardial  and renal  ischemia-reperfusion injuries; surgically induced oral lesions ; chemically induced osteoarthritis ; spinal cord contusion injury , and colitis [23, 50, 154] (see Burstein  for review). Anti-inflammatory effects are generally observed at higher CBD doses in vivo (e.g. ≥ 10 mg·kg −1 , i.p.); although, lower doses (e.g. ~1.5 mg·kg −1 , i.p.) have indicated efficacy in some studies . Research investigating the effects of CBD on inflammation in humans is limited and inconclusive [94, 133].
In terms of muscle-specific inflammation, one preclinical study has investigated the effect of high-dose CBD (i.e. 60 mg·kg −1 ·d −1 , i.p.) on transcription and synthesis of pro-inflammatory markers (i.e. IL-6 receptors, TNF-α, TNF-β1, and inducible nitric oxide synthase) in the gastrocnemius and diaphragm of dystrophic MDX mice (a mouse model of Duchenne muscular dystrophy) . In this investigation, CBD attenuated mRNA expression of each marker and reduced plasma concentrations of IL-6 and TNFα. Improvements in muscle strength and coordination, as well as reductions in tissue degeneration, were also reported at this dose. Lower, but still relatively high, CBD doses (20–40 mg·kg −1 ·day −1 , i.p.) had no functional benefits . Of course, it is important to recognise that EIMD and muscular dystrophy differ in their pathophysiology, and so the effects observed in MDX mice may involve mechanisms less relevant to EIMD (e.g. skeletal muscle differentiation, autophagy) .
While CBD could potentially aid in muscle recovery, other anti-inflammatory agents, such as ibuprofen (a non-steroidal anti-inflammatory drug [NSAID]) have been reported to attenuate exercise-induced skeletal muscle adaptation . The precise mechanism(s) underpinning these effects have not been fully elucidated, although it may be that the prevention of inflammation inhibits angiogenesis and skeletal muscle hypertrophy . Human trials also suggest that ibuprofen may not influence EIMD, inflammation, or soreness [144, 175]. Thus, if CBD exerts its effects via similar mechanisms, it could possibly attenuate the benefits of training without influencing muscle function or soreness. Future studies investigating this are clearly warranted to clarify such issues and elucidate the potential benefits of CBD.
Neuroprotection—Concussion and Subconcussion
Recent estimates suggest that 6–36% of high school and collegiate athletes in the USA have experienced more than one concussion , potentially predisposing them to long-term neurodegenerative diseases  and an increased risk of suicide . Concussion is a distinct form of mild traumatic brain injury (TBI) in which a biomechanical force temporarily disrupts normal brain functioning causing neurological–cognitive–behavioural signs and symptoms . Similar injuries that do not produce overt (acute) signs or symptoms are termed “subconcussions” . In TBI, the primary injury occurs as a result of the biomechanical force; secondary injury is then sustained through a complex cascade of events, including HI, cerebral oedema, increased intracranial pressure, and hydrocephalus . These processes are, in turn, related to a number of detrimental neurochemical changes, including glutamate excitotoxicity, perturbation of cellular calcium homeostasis, excessive membrane depolarisation, mitochondrial dysfunction, inflammation, increased free radicals and lipid peroxidation, and apoptosis . While the primary injury may not be treatable, interventions that attenuate secondary sequelae are likely to be of benefit .
Only one study  has investigated the biochemical and neuropsychological effects of CBD in an animal model of TBI. Here, C57BL/6 mice were given chronic CBD treatment (3 μg·day −1 , oral) 1–14 and 50–60 days post- (weight drop) brain insult. CBD attenuated the behavioural (e.g. anxious and aggressive behaviour, depressive-like behaviour, impaired social interactions, pain-related behaviours) and some of the cortical biochemical abnormalities were observed. Specifically, CBD tended to normalise extracellular glutamate, d -aspartate, and γ-aminobutyric acid concentrations in the medial prefrontal cortex, suggesting a reduction in excitotoxicity. However, neuronal damage was not measured directly in this study .
Other preclinical studies have investigated the impact of CBD on different animal models of acute neuronal injury, in particular, acute cerebral HI [4, 13, 31, 68, 69, 80, 81, 83, 100, 105, 127, 129, 142, 143, 153]. Studies administering a single (acute) dose of CBD shortly post-HI (e.g. ≤1 h) have produced inconsistent results. For instance, while Garberg et al. [68, 69] found no effect of CBD (1 or 50 mg·kg −1 , i.v.) on HI-induced neuronal damage in piglets, others observed neuroprotection at similar doses (e.g. 1 mg·kg −1 , i.v [105, 143]., 1 mg·kg −1 , s.c [127, 142]., and 5 mg·kg −1 , i.p .) in piglets and rats. When given chronically, or repeatedly within a short timeframe proximal to the HI event, however, CBD appears to be neuroprotective. Effective dosing strategies have varied and included initiating treatment several days pre-HI (e.g. 100 or 200 μg·day −1 , intracerebroventricular 5 days; Wistar rats ), shortly pre- and/or post-HI 1 , and up to 3 days post-HI (e.g. 3 mg·kg −1 ·day −1 , i.p. 12 days; ddY mice ). Thus, chronic CBD treatment may be more effective than acute intervention. While “pre-incident” dosing might also be beneficial, it is noted that in practice, this would require humans at risk of TBI to use CBD chronically as a prophylactic.
The precise mechanism(s) underpinning the neuroprotective effects of CBD are not completely understood (see Campos et al.  for review), but may involve decreased inflammation, oxidative stress, and excitotoxicity [142, 143] and increased neurogenesis . Preclinical studies have also demonstrated beneficial effects of CBD in other animal models of neurodegeneration (e.g. transgenic model of Alzheimer’s disease [34, 35], brain iron-overload [47, 48]). Collectively, these data suggest that research investigating the utility of CBD in ameliorating the harmful long-term effects of repeated sports concussions is warranted.
Nociceptive and Neuropathic Pain
Persistent pain is common in athletes . Nociceptive pain, which includes inflammatory pain, typically occurs with tissue damage; whereas neuropathic pain typically results from a lesion or disease in the somatosensory nervous system . Neuropathic pain is common among para-athletes with spinal cord injuries and can also arise with surgery (e.g. to treat an existing injury) or if there is repetitive mechanical and/or inflammatory irritation of peripheral nerves (e.g. as in endurance sports) .
Clinical trials investigating the combined effects of Δ 9 -THC and CBD (e.g. Sativex®) on chronic neuropathic pain have yielded promising initial results [87, 114, 151, 156]. However, the therapeutic effects of CBD administered alone have received limited clinical attention. Preclinical (in vivo) studies investigating the effects of CBD on neuropathic and nociceptive pain are summarised in Table Table2. 2 . Despite some methodological inconsistencies (e.g. the pain model, period of treatment, route of delivery), most preclinical studies appear to have observed a significant analgesic effect of CBD [29, 39–41, 51, 70, 75, 78], albeit somewhat less pronounced than the effects of Δ 9 -THC [29, 78] (e.g. Hedges’ g = 0.8 vs. 1.8 ) or of gabapentin (e.g. Hedges’ g = 2.0 ), a commonly used agent for treating neuropathic pain. Capsazepine co-treatment has also been reported to attenuate CBD-induced analgesia, suggesting that the effect may be mediated, at least in part, by the TRPV1 channel [40, 41, 51]. This mechanism is noteworthy as studies have implicated the TRPV1 in the development of mechanical hyperalgesia induced by muscle inflammation [66, 140].
Preclinical studies investigating the effect of CBD on neuropathic and nociceptive pain in vivo
|De Gregorio et al., (2019) ||Wistar rats||SNI||5 mg·kg -1 ·d -1 , s.c. 7 d||CBD sig. decreased mechanical allodynia on Tx day 7.|
|Casey et al., (2017) ||C57BL/6 mice||CCI||30 mg·kg -1 , s.c.||CBD sig. decreased mechanical allodynia 2 h, but not 0.5, 1, 4 or 6 h, post-Tx compared to baseline.|
|0.01, 0.1, 1, 10 or 100 mg·kg -1 , s.c.||CBD dose-dependently decreased mechanical and cold allodynia.|
|King et al., (2017) ||C57BL/6 mice||CT (Paclitaxel)||0.625–20 mg·kg -1 , i.p. 15 min prior to CT on days 1, 3, 5 and 7||1 and 20 mg·kg -1 CBD sig. attenuated the development of mechanical allodynia measured on Tx days 9 and 14, but not 21.|
|CT (Oxaliplatin)||1.25–10 mg·kg -1 , i.p. 15 min prior to CT on days 1, 3, 5 and 7||1.25–10 mg·kg -1 CBD sig. attenuated the development of mechanical allodynia measured on Tx days 2, 4, 7 and 10.|
|CT (Vincristine)||1.25–10 mg·kg -1 , i.p. 15 min prior to CT on days 1, 3, 5 and 7||CBD did not attenuate the development of CT-induced mechanical allodynia measured on Tx days 5, 10, 15 and 22.|
|Harris et al., (2016) ||C57BL/6 mice||CT (Cisplatin)||2 mg·kg -1 , i.p.||CBD sig. decreased tactile allodynia 1 h post-Tx.|
|0.5, 1 or 2 mg·kg -1 , i.p. 30 min prior to CT every second day for 12 d||CBD did not attenuate the development of CT-induced tactile allodynia measured on Tx days 6, 10 and 12.|
|Ward et al., (2014) ||C57BL/6 mice||CT (Paclitaxel)||2.5 or 5 mg·kg -1 ·d -1 , i.p. 15 min prior to CT on days 1, 3, 5 and 7||2.5 and 5 mg·kg -1 ·d -1 CBD attenuated the development of CT-induced mechanical allodynia.|
|Toth et al., (2010) ||CD1 mice||STZ Diabetes||0.1, 1 or 2 mg·kg -1 ·d -1 , i.n. 3 months||1 and 2 mg·kg -1 ·d -1 CBD sig. attenuated the development of thermal and tactile hypersensitivity compared to 0.1 mg·kg -1 ·d -1 CBD.|
|2 mg·kg -1 ·d -1 , i.n. 1 month||CBD did not alleviate developed thermal or tactile hypersensitivity.|
|1, 10 or 20 mg·kg -1 ·d -1 , i.p. 3 months||20 mg·kg -1 ·d -1 CBD sig. attenuated the development of thermal and tactile hypersensitivity compared to 1 mg·kg -1 ·d -1 CBD.|
|20 mg·kg -1 ·d -1 , i.p. 1 month||CBD did not alleviate developed thermal or tactile hypersensitivity.|
|Costa et al., (2007) ||Wistar rats||CCI||2.5, 5, 10 or 20 mg·kg -1 ·d -1 , oral 7 d||5, 10 and 20 mg·kg -1 ·d -1 CBD sig. decreased thermal and mechanical hyperalgesia on Tx day 7.|
|Nociceptive (Inflammatory) Pain|
|Genaro et al., (2017) ||Wistar rats||Incision||0.3, 1, 3, 10 or 30 mg·kg -1 , i.p.||3 mg·kg -1 CBD sig. decreased mechanical allodynia between 30- and 150-min post-Tx; 10 mg·kg -1 CBD sig. decreased mechanical allodynia 60 min post-Tx, only.|
|Hammell et al., (2016) ||Sprague-Dawley rats||FCA||0.6, 3.1, 6.2 or 62.3 mg·kg -1 ·d -1 , t.c. 4 d||6.2 and 62.3 mg·kg -1 CBD sig. decreased pain-related behaviour on Tx day 4 and thermal hyperalgesia on Tx days 2, 3 and 4.|
|Costa et al., (2007) ||Wistar rats||FCA||20 mg·kg -1 ·d -1 , oral 7 d||CBD sig. decreased thermal and mechanical hyperalgesia on Tx day 7.|
|Costa et al., (2004) ||Wistar rats||Carrageenan||5, 7.5, 10, 20 and 40 mg·kg -1 , oral||5, 7.5, 10, 20 and 40 mg·kg -1 ·d -1 CBD sig. decreased thermal hyperalgesia 1–5 h post-Tx.|
|Costa et al., (2004) ||Wistar rats||Carrageenan||10 mg·kg -1 , oral||CBD sig. decreased thermal hyperalgesia 1 h post-Tx.|
The ‘Treatment Effects’ described are in comparison to a vehicle condition, unless otherwise stated
CBD Cannabidiol, CCI Chronic Constriction Injury, CT Chemotherapy, FCA Freund’s Complete Adjuvant, i.n. Intranasal, i.t. Intrathecal, s.c. Subcutaneous, SNI Spared Nerve Injury, STZ Streptozotocin, t.c. Transcutaneously, Tx Treatment
It is important to recognise that the analgesic effect of CBD likely depends on several factors, including the treatment dose and the type of pain involved. Indeed, low doses of CBD (e.g. ≤ 1 mg·kg −1 , i.p.) do not consistently attenuate pain [29, 41, 70, 75, 101]; while higher doses are sometimes found to be more , and other times, less , efficacious than moderate doses in preclinical studies (Table (Table3). 3 ). This highlights the importance of determining a therapeutic dose for CBD in analgesia. Data from King et al.  also demonstrate the selectivity of the response, indicating that CBD only effective in attenuating the development of neuropathic pain induced by certain chemotherapeutic agents (i.e. paclitaxel and oxaliplatin but not vincristine). Thus, placebo-controlled trials of CBD in treating pain in clinical populations and athletes are warranted.
7 Things You Need to Know About CBD
This plant compound found in marijuana may be able to help drive gains by wiping out pain and boosting recovery.
While everyone knows that a few tokes of weed will get you high, revival of research from the ’70s has found that some compounds in the plant can help with a wide range of ailments, like chronic pain, depression, symptoms from chemotherapy, and multiple sclerosis. That’s one reason that the plant is now legal in 10 states (as of press time) and allowed to be consumed for medical purposes in another 22. The other: Huge amounts of tax money from marijuana sales are filling up state coffers—Colorado alone took in more than $247 million last year. Put simply: The marijuana market is blowing up.
But it’s cannabidiol (CBD)—the straitlaced brother to the chemical in marijuana (THC) that gets you stoned—that’s been taking the nation by storm. This seemingly miraculous compound has been found to jump-start healing in your body by regulating the immune system and reducing inflammation, all without any harmful side effects. Below, we go over what you need to know about CBD oil.
What Every Guy Should Know About THC and CBD in We.
Get familiar with the compounds in marijuana with this explainer.
How CBD Helped Me
Last summer, I hurt my hand trying to yank up some stuck luggage. The excruciating pain, and the advice from an orthopedist, meant that I had to stop lifting anything heavy, pretty much avoiding any exercise that required my hands.
After six weeks, my hand was feeling fine, so I started deadlifting again. Two weeks later, I tried to hoist my old working weight, but on my fourth set, a burst of pain radiated through my lower back. The next morning, I could barely roll out of bed without experiencing a wave of throbbing pain—I’d hurt my back before, but this was next-level. Struggling to even put socks on, I hobbled into the bathroom, pulled open a drawer, and grabbed some CBD cream that was sent to me for review months ago. I squirted two pumps in my palm and slathered it on my back and forgot about it. I did that twice a day for the next two days.
On the third day, I woke up feeling great, rolled out of bed with little to no pain, and was able to function normally. I was shocked. I expected a long recovery full of frustration, but I was pretty much healed after only three days. I waited one more week before going back into the gym and then did some light squats and deadlifts with hardly a twinge or notion of pain. Anecdotal evidence or not, a bottle of CBD cream or oil will now always be a part of my training regimen.
Does CBD Oil Actually Work?
Or is the recent buzz much ado about nothing?
boonchai wedmakawand / Getty
What is CBD?
The human body has a specific biological network called the endocannabinoid system, which is made up of neurotransmitters and receptors specifically attuned to cannabinoids. These compounds can produce healing effects on our cognitive and physical processes when they bind to specific receptors.
Tetrahydrocannabinol (THC) is probably the most well-known cannabinoid—and most prevalent in recreational weed—as it’s what gives you that stereotypical, euphoric high when smoked or ingested.
Cannabidiol (CBD), which is found in high concentrations in hemp or industrial marijuana, is the next most common cannabinoid. It doesn’t produce any psychoactive effects, so, up until recently, it was thought to not act on the human body at all. Well, we were wrong.
Ian Cuming / Getty
What Does CBD Do?
CBD binds to receptors, called CB1 and CB2—which are found in your brain, nervous system, muscle tissue, and even some organs—and has been shown to boost functioning of the immune and nervous system as well as better manage pain.
“CBD tends to regulate and normalize these receptors in your muscles, in your immune system, in your spleen, in your kidney, your liver,” says Bomi Joseph, Ph.D., director of the Peak Health Foundation and a noted plant compound researcher.
How is it Used?
A 2018 meta-analysis of multiple studies on the compound published in the journal Frontiers in Immunology concluded that CBD “has clearly shown” effects for reducing and treating anxiety, post-traumatic stress disorder, depression, and psychosis. There are also CBD-THC hybrids, which have been used to treat multiple sclerosis, a disorder that turns the immune system against the nervous system, damaging nerves and affecting balance and muscle control. Some medications using CBD have helped to treat epilepsy in children and teens, with studies showing the compound can reduce and even eliminate seizures altogether.
Other studies show that CBD can boost and support brain health. Additional research published in the journal Cell Communication and Signaling found that CBD could spur the growth of new neurons in the brain and protect brain cells. And another review from 2017 found that CBD has antioxidant effects that also help keep the brain from degenerating from the effects of old age or mental disorders like schizophrenia.
Sally Anscombe / Getty
What is the Correct Dosing?
The short answer is, we don’t know. The Food & Drug Administration (FDA) doesn’t regulate the compound, so formulations, dosages, and quality control are all over the place. And since the consumer market is exploding and regulations are almost nonexistent, there is a glut of CBD products coming from overseas that aren’t quite kosher.
“Most of the CBD products that are flooding the market now are synthetic,” Joseph says. “Though we can come close, we can’t completely mimic nature.” Joseph compares synthetic CBD to the margarine form of vegetable oil—you can hydrogenate it so it is similar to butter, but at its core it’s not the same thing. Synthetic CBD won’t work as well as the natural stuff.
General Dosing Guidelines
It’s hard to give the optimum dose, as it depends on the concentration and other environmental factors. It’s best to start out with a low dose and see how you feel, but here are a couple of guidelines.
- 10 milligrams a day for a 5’9″ male
- 15 milligrams for someone 6’2″ and athletic
What Should You Look For in CBD Products
When buying a CBD product, make sure that it’s plant-derived, whether it’s from hops or hemp or feverfew. Some of the better brands out there, like Extract Labs, Medical Marijuana, Nanocraft, Real Scientific, and Green Helix, produce products that have clear, third-party lab-tested results available and are some of the highest-quality plant-derived CBD products around. And currently—the laws are still a bit murky and evolving—you can legally get CBD products in all 50 states, though there are some minor restrictions depending on where you live.
Congress is working on legislation right now that would make industrial hemp legal in the U.S., which would mean any CBD derived from hemp would also be legal nationwide. Right now there are numerous shops online that can legally sell you CBD products, and brick-and-mortar stores are popping up all over the place, so check your local listings.
Since CBD products aren’t regulated by the FDA, there are no clear instructions on what kind of product to use and how to properly dose yourself. But taking CBD isn’t the same as taking a drug, so you don’t need to worry about overdosing or getting sick, says Prudence Hall, M.D., medical director of the Hall Center in Santa Monica, CA. “I’ve talked to almost 400 patients in the last year who’ve been using CBD, [and] I haven’t heard anyone say anything negative—sometimes a few people will mention that they feel a little more fatigued.” A 2018 study from the University of Wisconsin stated that twice-daily use of CBD was “generally well-tolerated” and any adverse effects were “mild in severity.”
James Baigrie / Getty
Can CBD Help My Gains?
Though taking CBD to enhance performance is not well-studied, there are some athletes out there who use CBD and THC extracts to help with recovery and pain management. A few well-known athletes, including UFC fighters Yair Rodriquez and Nate Diaz, ultramarathon runner Avery Collins, and Tennessee Titans linebacker Derrick Morgan, have come out and said that they use CBD to help with recovery, heal sore muscles and achy joints, and tamp down general inflammation. Using CBD in your own athletic endeavors can help you with your gains, but not by making you directly stronger or giving you more energy, like steroids or stimulants.
Where CBD will benefit the weekend warrior is by making recovery from intense exercise and minor injuries faster. “What happens when you pull a muscle or get injured is that there’s an immediate inflammation of that area because your body is trying to confine it,” Joseph says. “CBD tells that inflammation signal to go down. That’s what everybody feels initially, but CBD actually speeds up the recovery.”
Should You Take CBD Oil Before or After a Workout?
Home » Blog » Should You Take CBD Oil Before or After a Workout?
CBD is an ally to athletes, helping them push harder during workouts and recover quicker after meeting their goals.
Once you understand the beautiful relationship between CBD and exercise , it is then time to start adding it to your routine. But is it better to take CBD oil before or after you exercise?
The short answer is that CBD oil is effective both before and after workouts. Before your workout, it can help to boost your energy and relax your muscles. Afterward, it can help soothe post-exercise inflammation.
Whether to take CBD oil before or after workout to experience its best effects for your specific body depends on your exercise challenges and goals. In this short guide, we’ll go over your options.
- CBD can help boost performance during a workout, then soothe post-exercise inflammation after one is completed.
- When you should take CBD oil for working out largely depends on the issues you’re facing throughout your fitness journey.
- Many athletes use CBD topicals to target specific areas that experience soreness after a long workout.
Assessing Your Workout Challenges
What keeps you from achieving your personal best during your workouts? Typically, there’s a range of issues that can keep you from meeting your full potential at the gym-or even getting there in the first place.
So, which set of these challenges best describe your fitness obstacles?
- I feel low-energy before my workouts
- I skip warming up or warming up takes longer than I want it too
- I start to feel sore before I reach my goal
- I have pre-event or pre-workout jitters
- I experience muscle soreness, burning, and discomfort after my workouts
- My long muscle recovery time keeps me from hitting the gym again as soon as I want to
- My physical discomfort impacts my sleep and energy levels
If the statements in Set A describe your issues to a T, you could benefit from taking CBD oil before your workouts. If those in Set B are closer to your experience, CBD oil could lend a helping hand as you recover. Whether you prefer a CBD tincture, a CBD capsule , or a daily CBD gummy , there are many ways to get your daily CBD oil dosage before gym time.
Do all of these statements apply to you? You’re not alone!
Many people benefit from incorporating CBD into their pre- and post-workout rituals and routines to help support muscle recovery. Next, we’ll take a closer look at how and why CBD can benefit you before and after you hit the gym.
Taking CBD Before a Workout
To get in a serious workout, you need to be in the right mindset and at the right physical energy level. If you’re looking for that extra edge before you get going, taking CBD oil beforehand could potentially help.
Let’s take a look at the problems we outlined above under Set A.
A CBD dietary supplement can potentially help with the following issues:
- Low energy – Some people drink coffee before a workout to get revved up. However, there are potential drawbacks like dehydration and a post-caffeine crash! In contrast, a CBD dietary supplement can support your body holistically, leading to increased energy throughout the day.
- Warming up – You know it’s helpful to stretch and warm-up before your workout. What causes sore muscles in the first place? In many cases, tension plays a significant role. CBD is thought to help reduce muscular tension and support healthy blood flow, which can reduce the time it takes to get warmed up before your workout.
- Delaying soreness – Sometimes, you’re only a few minutes into a workout when your body starts to protest. It’s important to listen to those signals. However, CBD for athletes can potentially help delay their onset. How? CBD helps the body return to its baseline state (homeostasis). With your internal systems communicating well, your body may not react so strongly to the first signs of stress and fatigue. That way, you can get in more reps or more seconds of your workout.
- Reducing pre-workout jitters – Some athletes are worried about achieving their personal best during a particular training session. Others simply want to avoid looking unpracticed on a new weight machine. If stress keeps you from achieving your goals, CBD for your pre-workout routine could potentially help soothe your nerves.
How to Use CBD Before Your Workout
After reading through these potential benefits, you might be eager to start using CBD as part of your pump-up routine.
To that end, consider trying out one of the following techniques:
- 1-2 hours before your workout, drink a smoothie of fruits, greens, protein, and CBD oil. This can ensure you have the fuel you need to get going. You should start to experience the beneficial effects of CBD oil during your workout.
- Just before warming up, take CBD oil sublingually. While many people prefer to chew (gummies) or drink their CBD (oil), holding it under your tongue is the fastest way to feel its effects. Simply hold your CBD oil under your tongue for thirty seconds, then swallow any remaining liquid.
While CBD oil is a highly effective way to consume CBD, there are some potential drawbacks. If you’d prefer a more discreet, non-liquid option, consider the following:
- CBD capsules – Take one hour before working out
- CBD gummies – Take 1-2 hours before working out
CBD After Exercise
In other cases, the issue isn’t completing your workout-it’s going too hard!
Testing your personal limits is an essential part of growth. At the same time, excessive burning, stiffness, and discomfort after exercise can actually hinder your progress. When you’re tired and sore, it’s that much harder to meet your goals the next time around.
If you’re determined to push through the physical unease, it can have other negative results as you begin to rely on compensatory muscles.
Have you been looking for a way to recover faster?
In most cases, rest, hydration, and property nutrition are key to recovery. However, CBD could also help accelerate the timeline to relief.
CBD is thought to help with the following issues:
- Post-exercise inflammation – What causes soreness and burning? Modern science suggests that post-exercise inflammation plays a significant role. When we work out, we create microscopic tears across our muscles. The body perceives these tears as injuries and mounts an immune system response to hasten repair. The only problem is the resulting discomfort. By reducing inflammation, CBD can help the body heal itself with less discomfort.
- Tension – When one muscle is exhausted or sore, the others around it can stiffen up, acting like a protective shield. However, the overall stiffness can reduce your mobility and even lead to injury. CBD can help your whole body relax and recover.
- Response to discomfort – As we’ve noted, CBD can help your body return to its baseline state more quickly. In particular, it can help your Endocannabinoid System
(ECS) function better, letting your body know when more resources are needed and when it’s okay to calm down. This holistic support can help reduce your feeling of distress and discomfort.
How to Use CBD Post-Workout
CBD oil can be a great post-workout ally. Many people find that post-exercise inflammation sets in between twelve and thirty-six hours after they’ve worked out.
CBD oil helps you get ahead of the curve by addressing post-exercise inflammation before it reaches its peak. To that end, try out the following ideas:
- CBD oil self-massage – After a day of vigorous exercise, it can be incredibly soothing to give yourself a massage. Communicate love and care to the affected muscles, moisturize your skin, and experience the soothing effects of CBD all at once!
- CBD oil when issues arise – As we’ve discussed, CBD oil can take effect quickly when consumed sublingually. Just be sure to take it as soon as the first sign of post-exercise soreness arises, rather than waiting for a peak of your symptoms.
Besides CBD oil, numerous other products can support your holistic health.
For example, a CBD Bath Bomb can help you unwind your muscles and achieve full relaxation. We recommend getting in the tub before bed! In contrast, CBD Sports Cream is useful any time, day or night.
Apply it wherever you’re experiencing soreness.
CBD for Holistic Health
So far, we’ve discussed the benefits of taking CBD just before or after your workouts, and whenever specific issues arise. However, another option is taking a CBD supplement daily.
As we’ve noted, CBD has the potential to support your overall health in terms of:
- Maintaining homeostasis
- Stress response
- Energy levels
- Sensations of discomfort
- Post-exercise inflammation
Besides these benefits, it can also help to improve your sleep cycles.
It goes without saying that sleep plays an important role in your overall health. Our bodies conduct important repair work as we sleep. Likewise, getting enough shut-eye ensures we have adequate energy to conquer each day.
Many people find that taking CBD as a daily supplement leads to increased vitality over time. Of course, you can always take a dose of CBD oil daily and double up with gummies, sports creams, or other CBD products for any specific symptoms that arise throughout your fitness journey.
Choosing Your CBD Product
Now that you know when to take CBD , the only step left is choosing the right product. As you shop for CBD products, look for high-quality products from naturally derived ingredients. Fantastic options for athletes include:
- Full-Spectrum CBD – This type of CBD contains other cannabinoids found in the hemp plant including CBG, CBN, and THC. In line with legal requirements, hemp-derived CBD contains little to no THC and does not have psychoactive effects.
- CBD isolate – Some people find that pure CBD provides a sufficient boost without the presence of other cannabinoids. CBD isolate is another potent option.
Finding the best CBD product for you is important to experience its benefits in full. Whether you opt for CBD capsules, topical CBD, CBD tincture, there are numerous ways to consume and enjoy CBD.
Boost Your Performance With Resilience CBD
Whether you are looking for ways to ease soreness, support immunity, or boost athletic performance, CBD is a great product, offering many health benefits. At Resilience CBD, we formulate products with athletes’ needs in mind. Reaching your goals and surpassing your personal limits requires mental and physical strength. And CBD’s soothing properties can help provide the support you need to rest, recover, and thrive in your fitness routine.
Shop our line of CBD oils for daily use and explore our CBD topicals for targeting post-exercise inflammation. After all, we’re called Resilience for a reason.
Written by: Michael Tatz | Linkedin
Michael Tatz is the Co-Founder of Resilience CBD, and a passionate leader in the health & fitness world helping others rise to and crush their wildest goals. A former Division 1 college wrestler, Army Officer, and investment manager at Goldman Sachs, he has pushed his body and mind to the limits on the mats, dressed in camo, and in the boardroom.
Today, he spends his time leading Resilience CBD to develop the absolute best recovery products for athletes everywhere. Resilience was founded after CBD personally impacted Michael’s life, and the brand was built to partner with everyday athletes in pursuit of conquering their most difficult challenges, rebounding after their toughest performances, and rising to their goals that once seemed impossible.