CBD oil is made from hemp plants. It may help treat pain, anxiety, and seizures. Here is what you should know before trying it. The original. The product that started the CBD movement, but more powerful than ever. Packed with CBD, THC, CBN, CBC and other beneficial cannabinoids and terpenes. A long-time favorite of those looking for comfort, our 1:1 ratio is full-spectrum CBD tincture that features CBD, THC, the minor cannabinoids THCa and…
CBD Oil Benefits vs. Side Effects
While it may be helpful, it may not be safe for all
Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman’s World, and Natural Health.
Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more.
Meredith Bull, ND, is a licensed naturopathic doctor with a private practice in Los Angeles. She helped co-author the first integrative geriatrics textbook, “Integrative Geriatric Medicine.”
CBD oil is said to have a variety of possible health benefits. It is used as an appetite stimulant, a sleep aid, a treatment for skin conditions like eczema and psoriasis, for relief of pain, to prevent seizures, and much more.
Though derived from cannabis, the same plants grown for marijuana, CBD oil is not he same as pot. But that doesn’t mean that CBD oil is 100% safe. Some possible side effects, like dry mouth, may be fairly minor. Others, like anxiety, are potentially more significant. And certain potential side effects may even make using CBD oil inadvisable for some people.
This article goes over what CBD is used for, the possible side effects, and what you should look for if you choose to buy CBD.
What Exactly Is CBD Oil?
CBD oil is a hemp plant extract known as cannabidiol mixed with a base (carrier) oil like coconut oil or hemp seed oil. CBD oil comes from Cannabis indica and Cannabis sativa plants.
CBD Oil Benefits
People who support the use of CBD claim that CBD oil benefits people with a variety of health problems. CBD oil is said to be good for:
- Drug use and withdrawal
- High blood pressure
- Muscle spasms
- Poor appetite
- Skin conditions like eczema and psoriasis
As CBD has gained popularity, researchers have been trying to study it more. Still, there has not yet been a lot of clinical research focused on finding evidence to back up these health claims.
Here’s a deeper dive into what is known about a few of the purported health benefits of CBD oil.
A 2015 review of research that was published in the journal Neurotherapeutics suggested that CBD might help treat anxiety disorders.
The study authors reported that CBD had previously shown powerful anxiety-relieving effects in animal research—and the results were kind of surprising.
In most of the studies, lower doses of CBD (10 milligrams per kilogram, mg/kg, or less) improved some symptoms of anxiety, while higher doses (100 mg/kg or more) had almost no effect.
The way that CBD acts in the brain could explain why this happens. In low doses, CBD might act the same as the surrounding molecules that normally bind to the receptor that “turns up” their signaling. However, at higher doses, too much activity at this receptor site could produce the opposite effect.
There have not been many trials to look at CBD’s anxiety-relieving effects in humans. However, one was a 2019 study published in the Brazilian Journal of Psychiatry.
For the study, 57 men took either CBD oil or a sugar pill with no CBD in it (placebo) before a public-speaking event.
The researchers assessed the participants’ anxiety levels using measures like blood pressure and heart rate. The researchers also used a reliable test for mood states called the Visual Analog Mood Scale (VAMS).
The men who took 300 milligrams (mg) of CBD oil reported less anxiety than the men who were given a placebo; however, the men who took 100 mg or 600 mg of CBD oil did not experience the same effects.
CBD oil might help people with substance use disorder, according to a 2015 review published in the journal Substance Abuse.
The review looked at the findings from 14 published studies. Nine of the studies looked at the effects of CBD on animals and five looked at the effects on humans.
The researchers reported that CBD showed promise for treating people with opioid, cocaine, or psychostimulant use disorders.
However, the effects of CBD were quite different depending on the substance. For example, CBD without THC did not decrease withdrawal symptoms related to opioid use.
On the other hand, it did reduce drug-seeking behaviors in people using cocaine, methamphetamine, and other similar drugs.
Some experts suggest that CBD could help treat cannabis and nicotine dependence, but more research is needed to provide this theory.
Some studies have suggested that CBD oil may benefit the skin.
A 2020 paper, for example, found that CBD oil may help reduce inflammation, which could be useful for treating a variety of skin conditions including allergic dermatitis, acne, and psoriasis.
Proponents say CBD oil has benefits for people with cancer. Although some studies have shown promise, there have been no large studies proving the benefits of CBD oil as a cancer treatment.
Other studies suggest that CBD might interact with cancer drugs.
If you have cancer and are considering CBD, talk to your oncologist first about whether or not it is safe for you to use.
High Blood Pressure
A 2017 study found that CBD oil may reduce the risk of heart disease because it can lower high blood pressure in some people.
For the study, nine healthy men took either 600 mg of CBD or the same dose of a placebo. The men who took CBD had lower blood pressure before and after experiencing stressors like exercise or extreme cold.
The study also looked at the amount of blood remaining in the heart after a heartbeat (stroke volume). The stroke volume in the men who took CBD was lower than in was in the placebo group, meaning their hearts were pumping more efficiently.
The study suggested that CBD oil could be a complementary therapy for people with high blood pressure that is affected by stress and anxiety.
However, there is no evidence that CBD oil can treat high blood pressure on its own or prevent it in people at risk. While stress can complicate high blood pressure, it does not cause it.
Proponents say CBD oil has benefits as a sleep aid, but research so far is inconclusive.
A 2017 review pointed out that many studies have been small and limited. However, the authors also noted that because cannabinoids seem to have an effect on the sleep-wake cycle, their potential as a sleep aid is worthy of additional research.
In June 2018, the Food and Drug Administration (FDA) approved a CBD oral solution called Epidiolex.
Epidiolex is used to treat two rare forms of epilepsy in children under the age of 2: Dravet syndrome and Lennox-Gastaut syndrome. These are very rare genetic disorders that cause lifelong seizures starting in the first year of life.
Other than for these two disorders, CBD’s effectiveness for treating seizures is not known. Even with Epidiolex, it’s not clear if the anti-seizure effects are from CBD or another factor.
However, there is some evidence that CBD interacts with seizure medicines like Onfi (clobazam) and raises their concentration in the blood. More research is needed to understand the link.
Possible CBD Oil Side Effects
Clinical research has shown that CBD oil can cause side effects. The specific side effects and their severity varies from one person to the next and from one type of CBD to another.
Some common CBD side effects people report include:
- Changes in appetite
- Changes in mood
- Dizziness or fatigue
- Dry mouth
Do not drive or use heavy machinery when taking CBD oil—especially when you first start using it or switch to a new brand. Remember that some products do contain THC, even in small amounts.
Your healthcare practitioner may advise against using CBD oil if you:
- Have liver disease: CBD oil may increase liver enzymes, which is a marker of liver inflammation. Talk with your healthcare provider before taking CBD oil. You may need to have your liver enzymes checked regularly if you decide to use it.
- Have eye issues: CBD oil may also cause eye-related side effects. A 2018 study found that it may increase pressure inside the eyes. For people with glaucoma, this can make the condition worse. Some people also report dry eyes as a side effect of CBD oil.
- Are pregnant or nursing: You should not use CBD oil if you’re pregnant or breastfeeding. Even though the effects of CBD are not fully understood, it does pass through the placenta.
The American Academy of Pediatrics (AAP) further states that pregnant people should not use marijuana because of the potential risks to a developing fetus.
Can CBD Oil Get You High?
CBD oil does not get you high. Although it is from a plant that is in the same family as the marijuana plant, it does not contain tetrahydrocannabinol (THC), the compound responsible for this feeling.
|A component of the hemp plant||Separate plant in the hemp family that contains CBD and hundreds of other compounds.|
|No or trace amounts of THC||Significant amounts of THC|
|Works receptors in the brain, but not those that induce psychoactive effects (e.g., opioid receptors that help control pain, glycine receptors that impact mood control)||THC binds to cannabinoid receptors in the brain to create “high” feeling|
What CBD Oil Can Interact With
CBD oil can interact with medications, including many that are used to treat epilepsy. One of the reasons for this has to do with how your body breaks down (metabolizes) drugs.
Cytochrome P450 (CYP450) is an enzyme your body uses to break down some drugs. CBD oil can block CYP450. That means that taking CBD oil with these drugs could make them have a stronger effect than you need or make them not work at all.
Drugs that could potentially interact with CBD include:
- Anti-arrhythmia drugs like quinidine
- Anticonvulsants like Tegretol (carbamazepine) and Trileptal (oxcarbazepine)
- Antifungal drugs like Nizoral (ketoconazole) and Vfend (voriconazole)
- Antipsychotic drugs like Orap (pimozide)
- Atypical antidepressants like Remeron (mirtazapine)
- Benzodiazepine sedatives like Klonopin (clonazepam) and Halcion (triazolam)
- Immune-suppressive drugs like Sandimmune (cyclosporine)
- Macrolide antibiotics like clarithromycin and telithromycin
- Migraine medicine like Ergomar (ergotamine)
- Opioid painkillers like Duragesic (fentanyl) and alfentanil
- Rifampin-based drugs used to treat tuberculosis
Always tell your healthcare provider and pharmacist about all the medicines you take, including prescription, over-the-counter (OTC), herbal, or recreational drugs.
The interactions between these medications and CBD are often mild and you might not have to change your treatment. However, in some cases, you might have to change medications or space out your doses to avoid a reaction. Never change or stop medication without talking to your provider.
What’s a Safe Dosage of CBD Oil?
There are no guidelines for use, nor is there a “correct” dose of CBD oil. That said, the average dose range is from 5 mg to 25 mg.
Available forms include:
- Tinctures (CBD oil mixed with a base oil)
Which you choose largely comes down to your preference and what you hope to get in terms of effects. For example, putting the oil under your tongue can produce effects more quickly than swallowing a capsule that needs to be digested.
Each product works a bit differently, depending on the form, so it’s important to follow the provided directions.
How to Calculate a CBD Dose
Sprays, gummies, and capsules are easy to use because their doses are pre-measured.
Tinctures are a bit more challenging. Most oils come in 30-milliliter (mL) bottles and include a dropper cap to help you measure.
But some tinctures have concentrations of 1,500 mg per 30 mL, while others have 3,000 mg per mL or more. That means figuring out the exact amount of CBD per milliliter of oil requires a little math.
To determine an exact dose of CBD, remember that each drop of oil equals 0.05 mL of fluid. This means that a 30-mL bottle of CBD oil will have about 600 drops in it.
If the concentration of the tincture is 1,500 mg per mL, one drop would have 2.5 mg of CBD in it (1,500 mg ÷ 600 drops = 2.5 mg).
Safer Buying Practices
Remember that CBD oils are unregulated. There’s no guarantee that a product is what it claims to be on its packaging. You also can’t know for sure that it’s safe and effective.
A 2017 study reported that only 31% of CBD products sold online were correctly labeled. Most had less CBD in them than was advertised, and 21% had significant amounts of THC.
If you are interested in buying CBD products, here are a few tips that can help you make the best choice:
- Buy American: Domestically produced CBD oil might be a safer option than those that have been imported.
- Go organic: Brands certified organic by the U.S. Department of Agriculture (USDA) are less likely to expose you to pesticides and other harmful chemicals.
- Read the product label: Don’t assume that every ingredient on the product label is natural. CBD products can also have preservatives, flavorings, or thinning agents in them. If you don’t recognize an ingredient, ask the dispenser what it is or check online.
Frequently Asked Questions
CBD oil comes in different forms:
- Isolates contain only CBD.
- Broad-spectrum oils have nearly all of the components of the plant (e.g., proteins, flavonoids, terpenes, and chlorophyll), but do not have THC. oils have all the compounds including THC (up to 0.3%)
Alternative medicine practitioners believe that the compounds provide more health benefits, but the is a lack of evidence to support these claims.
Not necessarily. While the names are sometimes used interchangeably, hemp oil can also refer to hemp seed oil, which is used for cooking, food production, and skincare products. CBD oil is made from the leaves, stems, buds, and flowers of the Cannabis indica or Cannabis sativa plant. It should contain less than 0.3% THC. Hemp oil is made from the seeds of Cannabis sativa and does not have TCH in it.
It would be hard to overdose on CBD oil. Research has shown that human tolerance for CBD is very high. One study reported the toxic dose would be about 20,000 mg taken at one time.
It depends on where you live, the type of product, how it was sourced, and its intended purpose (medical or recreational). In many states, you must be 18 or 21 to buy CBD oil. Check your state’s laws.
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Blessing EM, Steenkamp MM, Manzanares J, Marmar CR. Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics. 2015;12(4):825-36. doi:10.1007/s13311-015-0387-1
Scheau C, Badarau IA, Mihai LG, et al. Cannabinoids in the pathophysiology of skin inflammation. Molecules. 2020;25(3):652. doi:10.3390/molecules25030652
American Society of Clinical Oncology. Is CBD safe for people With cancer?
Babson KA, Sottile J, Morabito D. Cannabis, cannabinoids, and sleep: a review of the literature. Curr Psychiatry Rep. 2017;19(4):1-2. doi:10.1007/s11920-017-0775-9
Miller S, Daily L, Leishman E, Bradshaw H, Straiker A. Δ9-tetrahydrocannabinol and cannabidiol differentially regulate intraocular pressure. Invest Ophthalmol Vis Sci. 2018;59:5904-5911. doi:10.1167/iovs.18-24838
Bonn-Miller MO, Loflin MJE, Thomas BF, Marcu JP, Hyke T, Vandrey R. Labeling accuracy of cannabidiol extracts sold online. JAMA. 2017;318(17):1708–1709. doi:10.1001/jama.2017.11909
Cather JC, Cather JC. Cannabidiol primer for healthcare professionals. Proc (Bayl Univ Med Cent). 2020;33(3):376-379. Published 2020 Jul 6. doi:10.1080/08998280.2020.1775437
Bergamaschi MM, Queiroz RHC, Zuardi AW, Crippa JAS. Safety and side effects of cannabidiol, a Cannabis sativa constituent. Curr Drug Saf. 2011;6(4):237-249. doi:10.2174/157488611798280924
The original. The product that started the CBD movement, but more powerful than ever. Packed with minor cannabinoids and terpenes, this is a full spectrum tincture unlike any other.
Our tinctures are made by combining our powerful hemp extract with organic MCT oil. We use natural extracts to create our citrus and chocolate mint varieties. Each tincture tastes great and is even better for you.
what are customers saying about our cbd+thc oil.
how to use & dosing.
Start with taking one dropper full (1ml). We recommend taking with food for best absorption, but it is not required.
If you need additional relief, take up to 3 servings per day.
* Amount of cannabinoids approximated and is based on the most recent certificate of analysis.
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Sourced from the best hemp farms in the US, five™ CBD has the most stringent standards for our suppliers.
*Third party lab report that shows you what’s actually in the product.
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CBD Oil is a tried-and-true product that combines a CBD extract with some type of carrier oil. The best CBD oils contain a full spectrum CBD extract — and a clean, healthy carrier oil. CBD oil is known for its ability to activate your body’s endocannabinoid system, leading to inner balance in the process!
At five™ we believe that nature knows best, which is why we use a full spectrum CBD extract in all of our CBD products. This type of CBD features its namesake compound alongside cannabinoids like THC, terpenes like guaiol, and hundreds of other active ingredients. You won’t find any broad spectrum CBD or CBD isolate here.
Full spectrum CBD oil is defined as CBD oil that contains a full spectrum of hemp’s best compounds. Full spectrum CBD oil contains THC, CBD, other cannabinoids, terpenes, flavonoids, and more. Our full spectrum CBD oil meets an even higher standard: its CBD:trace cannabinoid ratio is 5:1.
Yes. Terpenes contribute to the entourage effect and make CBD even stronger. Some terpenes even bind to endocannabinoid receptors.
Cannabinoids are compounds found almost exclusively in cannabis/hemp. They get their name from their ability to activate your body’s endocannabinoid system. CBD is the most prevalent cannabinoid in hemp, but it’s far from the only one.
Yes. Studies from Israel have conclusively shown that the small amounts of THC and other trace cannabinoids present in full spectrum CBD oil make it far stronger. Trace cannabinoids also make full spectrum CBD easier to dose.
No, it is not. Because the plant grows with a miniscule amount of THC (.3% or less). While this is considered a non-psychoactive amount, the plant cannabinoid is still present.
The choice of spectrum is personal and based upon what the consumer prefers. Some have found that they prefer the synergistic way that the cannabinoids work together in a full spectrum product. Others have found their desired results with an isolate product. It is good to try different spectrums to see which yields the most positive results for you.
Because there is a scant amount of THC within the plant extract, it can metabolize in your system to where it is enough to cause a positive result on a urine test. You can contact the lab directly should you like to know exactly what is being tested for and if a full spectrum cbd product is allowed.
Terpenes are compounds that contribute to the note or scent of flowering and fruiting plants throughout the world. Anyone who has enjoyed aromatherapy blends with scents like Lavender have enjoyed a plant’s terpenes. In the hemp plant, these terpenes work with the other cannabinoids, synergistically, to compound the potential benefits.
Between the inner balance, the increased calm, and the improved sleep, it’s hard to know where to start! Full Spectrum CBD is known to activate various parts of the body’s endocannabinoid system, leading to an impressively long list of possible health benefits. Our customers say our Full Spectrum CBD Oil worked for them when products from other brands did not.
For reasons that are still being uncovered by science, CBD works best when it’s used in tandem with tiny amounts of THC. It’s thought that this CBD + THC combo activates the entourage effect, a phenomenon that refers to hemp’s compound + compound synergy, better than anything else. The end result? A CBD product you can actually feel.
THC also has benefits of its own. It binds directly to CB1 receptors within the brain, leading directly to reduced stress and natural upliftment. THC may also be especially helpful for those who want to stave off chronic pain.
No! While large amounts of THC can indeed get you high, our Full Spectrum CBD Oil contains only trace amounts of THC — 0.3% by product weight, to be exact. This isn’t nearly enough THC to get you high.
Very unlikely. Large amounts of THC may cause side effects like dry mouth or anxiety, but once again, our CBD Oil doesn’t contain nearly enough THC to trigger these unwanted effects.
You bet! All of our CBD + THC products, including our Full Spectrum CBD + THC Oil, are completely legal. That’s because they don’t contain more than the 0.3% THC permitted by Federal law.
That depends on several factors, including your age, weight, health status, and health goals. Long story short…CBD affects different people differently!
That being said, we recommend starting off with one full dropper of CBD oil per day. (Consider taking this daily dose in the evening if you’re experiencing sleep problems.) If you’re not getting the results you’re looking for within a few days, feel free to slowly up your dose.
Not quite. While these three hemp-derived cannabinoids are closely related — scientists call them “isomers” — they vary in several ways. Delta-8 and delta-10 tend to be a little milder than delta-9. They also bind slightly differently to endocannabinoid receptors, leading to slightly different physiological effects.
No. Our Full Spectrum CBD Oil isn’t designed for vaping. Its MCT oil base is healthy to ingest, but it can become harmful if vaporized.
CBD oil was the very first CBD product to hit the shelves, and it continues to be one of the most popular products on the market today. As a result, it’s pretty dang popular!
You can find CBD oil at health food stores, grocery stores, head shops, dispensaries, and other locations. You may even be able to find it at some gas stations (not that we’re recommending that or anything). But buying online is usually the best way to go when it comes to finding affordable CBD products from trustworthy CBD companies.
Convenience, price savings, transparency, and much more. Let’s take a look at these one by one.
One of the biggest benefits of buying online is convenience. Gone are the days when you had to drive all over town to find a decent CBD product. Now you can just hop online, read some reviews, and make your purchase! Premium CBD will soon be delivered to your door.
Another major benefit of buying online? Price savings. The CBD available at retail shops is usually priced higher than what you’d find online. Our CBD products are among the best on the market, but they’re also highly affordable.
Last but not least, buying CBD from a premium online brand offers complete transparency. You won’t find any salespeople rushing in to pressure you to buy here! Instead you’ll be able to read real customer reviews and view real Certificates of Analysis (COA) en route to making a pressure-free decision.
1:1 Drops, 15ml
A long-time favorite of those looking for comfort, our 1:1 ratio are full-spectrum CBD drops that features CBD, THC, the minor cannabinoids THCa and CBDa, as well as flavorful terpenes. Equal parts CBD to THC, this ratio is potent and powerful. It is ideal for unwinding at the end of the day and promoting a restful night’s sleep. Designed for more experienced users, this ratio contains the most THC of any of our ratios. Our 1:1 is designed for people with previous experience with cannabis who can tolerate more THC. Take the 1:1 for a balanced feeling with some psychoactivity.
Cannabis oil, Coconut oil
Exact cannabinoid content varies by batch and the amounts indicated here are based on formulation.
Intended for oral consumption. Use the measured droppers to apply drops under the tongue & hold for 15-30 seconds before swallowing. Onset time & tolerance varies per individual so please consume accordingly.
- Onset Time: 15 min – 2 hours
- Duration of Effects: 2-10 hours
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