CBD And Fish Oil

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Fish oil (FO) and phytocannabinoids have received considerable attention for their intestinal anti-inflammatory effects. We investigated whether the combination of FO with cannabigerol (CBG) and cannabidiol (CBD) or a combination of all three treatments results in a more pronounced intestinal antiin … Cannabidiol (CBD) is a powerful supplement with anti-inflammatory properties and has been proven to have the ability to help control difficult-to-manage symptoms and help treat several previously untreatable conditions. Among other things, CBD oil can help to fight cancer and irritable bowel diseases, improve schizophr CBD oil is one of the most talked about health supplements in the last few years. Discover its surprising relationship to omega-3 fatty acids!

Efficacy of combined therapy with fish oil and phytocannabinoids in murine intestinal inflammation

Fish oil (FO) and phytocannabinoids have received considerable attention for their intestinal anti-inflammatory effects. We investigated whether the combination of FO with cannabigerol (CBG) and cannabidiol (CBD) or a combination of all three treatments results in a more pronounced intestinal antiinflammatory action compared to the effects achieved separately. Colitis was induced in mice by 2,4-dinitrobenzenesulfonic acid (DNBS). CBD and CBG levels were detected and quantified by liquid chromatography coupled with time of flight mass spectrometry and ion trap mass spectrometry (LC-MS-IT-TOF). Endocannabinoids and related mediators were assessed by LC-MS. DNBS increased colon weight/colon length ratio, myeloperoxidase activity, interleukin-1β, and intestinal permeability. CBG, but not CBD, given by oral gavage, ameliorated DNBS-induced colonic inflammation. FO pretreatment (at the inactive dose) increased the antiinflammatory action of CBG and rendered oral CBD effective while reducing endocannabinoid levels. Furthermore, the combination of FO, CBD, and a per se inactive dose of CBG resulted in intestinal anti-inflammatory effects. Finally, FO did not alter phytocannabinoid levels in the serum and in the colon. By highlighting the apparent additivity between phytocannabinoids and FO, our preclinical data support a novel strategy of combining these substances for the potential development of a treatment of inflammatory bowel disease.

Keywords: cannabidiol; cannabigerol; fish oil; inflammatory bowel disease; phytocannabinoids.

© 2020 John Wiley & Sons Ltd.

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Why CBD & Omega-3?

Cannabidiol (CBD) is a powerful supplement with anti-inflammatory properties and has been proven to have the ability to help control difficult-to-manage symptoms and help treat several previously untreatable conditions. Among other things, CBD oil can help to fight cancer and irritable bowel diseases, improve schizophrenia symptoms, relieve anxiety, and enhance the quality of sleep.

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Pain Management

Of all the benefits offered by CBD, natural pain relief tops the list for many. Evidence suggests that cannabinoids may prove useful in pain modulation by inhibiting neuronal transmission in pain pathways. Some studies, including an investigation published in the Journal of Experimental Medicine, found that CBD significantly reduces inflammation in mice and rats – but it’s not only rodents that experience these effects. A 2008 review identified that CBD offered effective pain relief without inducing adverse side effects in patients.

Anti-Inflammatory Properties

One of the most important health benefits of CBD oil is its analgesic (pain relieving) effects. It’s thought that CBD interacts with receptors in the brain and immune system to reduce inflammation and alleviate pain.

Anti-Seizure Properties

Seizures occur when there’s a dramatic fluctuation of electrical activity in the brain. Over the years, several high profile cases have raised awareness of CBD’s anti-seizure properties, but it’s only recently that science has been able to confirm this link.

Combats Anxiety

While CBD is most commonly used to treat physiological symptoms, there’s a growing body of research that indicates it can also be useful as part of the treatment regimens for a range of mental health conditions, including anxiety.

Cancer-Fighting

Research indicates that CBD may be valuable in the treatment of cancer in many different ways. CBD, in addition to some of the other compounds found in cannabis, has an antitumor effect and can amplify the death of tumor cells in both colon cancer and leukemia.

Reduces the risk for Diabetes

CBD oil may reduce the risk of developing Diabetes. In a recent study, researchers set out to explore what effect CBD would have on non-obese, diabetes-prone female mice. Only 32 percent of the mice that received the CBD were diagnosed with Diabetes, compared to 100 percent of the untreated group.

CBD + Omega-3

CBD oil works by interacting with the body’s endocannabinoid system (ECS), which is a physiological system made up of neurotransmitters named endocannabinoids. These chemical messengers bind to and activate cannabinoid receptors, which triggers a multitude of critical physiological responses involved in the regulation of inflammation, pain, fertility, appetite, memory, and mood, among other biological processes. The cannabinoids present in CBD oil are also able to activate these cannabinoid receptors – and therefore, like our bodies’ own endocannabinoids, are able to exert positive effects on our health and wellbeing.

So Why Omega-3 + CBD?

In order to get the most out of our CBD supplements, the phytocannabinoids require a fat source in order to reach and stimulate the endocannabinoid receptors. Consuming CBD with a high-quality omega-3 supplement will dramatically increase the effects of your CBD supplement.

Evidence also indicates that omega-3 plays a crucial role in maintaining the proper functioning of your endocannabinoid system.

Most importantly, omega-3 helps to maintain your ECS by:

  • Maintaining and repairing cannabinoid receptors
  • Providing the body with the ingredients necessary to grow more cannabinoid receptors
  • Helping the body to synthesize endocannabinoids
  • Keeping the body’s omega-6 to omega-3 ratio low, which helps to maintain healthy receptor membranes
  • Aids in the conversion of one type of cannabinoid to another as needed
  • Helps to metabolically regulate the ECS by creating the enzymes that produce and degrade cannabinoids

For these reasons, it is vital to note that the only way for your body to reap the full range of benefits provided by CBD is to ensure that your dietary and/or supplementary intake of omega-3 is sufficient.

Who can benefit from CBDO3?

CBDO3 combines two of the worlds most powerful natural anti-inflammatory health products. Working together these ingredients complement one another and improve one another’s efficacy simultaneously. This product is ideal for people looking to relieve, stress and anxiety, to help improve sleep and focus. CBDO3’s high potency omega-3’s will help reduce inflammation in the body all while carrying the phytocannabinoids to the endocannabinoid receptors to promote healing and wellness in the body. This product is unique in the sense that its effects can be felt nearly immediately. So if you are looking to improve your health or relieve or alleviate any condition named above this CBDO3 is the product for you.

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Does CBD Oil Need Omega-3 to Work?

Every day, there seems to be a new article about the growing popularity of CBD oil. Some articles speculate on the enormous economic growth that is expected from CBD products over the next few years, while others focus on CBD’s potential for reducing chronic pain and alleviating anxiety. The third type of article comes from researchers who cite discrepancies between users’ glowing accounts and clinical testing that does not support these anecdotes.

So is CBD oil a massive hype or a science-based gift from nature? And if it happens to be the latter, what’s the best way to maximize its effects?

What Is CBD and What Does It Do?

CBD (short for cannabidiol) is a substance extracted from the flower and leaves of the hemp plant. Discovered in the 1940s, CBD is one of over 100 identified cannabinoids in the Cannabis plant, accounting for up to 40% of the plant’s extract. Unlike another prevalent cannabinoid (THC), CBD does not appear to create the psychoactive effects associated with marijuana (1, 2).

The bulk of the research on CBD has focused on its ability to affect cell metabolism through what is called the endocannabinoid system. This system is involved in a wide range of physiological functions, including the regulation of our mood, inflammation response, immune system, and metabolism.

The precise mechanisms of how CBD works are not entirely clear; however, the main hypothesis is that CBD has a significant influence on the endocannabinoid system by mimicking the body’s own endocannabinoids.

What Are Endocannabinoids?

Found in every organ and tissue of the body, endocannabinoids are important lipids made naturally from the cells’ content of omega-3s and omega-6s. These lipids stimulate specialized cell membrane receptors, which in turn prompt the cell to perform specific tasks.

For instance, when certain types of endocannabinoids activate the endocannabinoid receptor CB1, the cell increases energy storage. Similarly, when endocannabinoids activate another receptor (CB2), they help to reduce pro-inflammatory cytokines (3). Note: These are the same receptors that cannabinoids (like CBD) act on, too.

THC, CBD, and CBN are three cannabinoids found in Cannabis. Mimicking the body’s endocannabinoids, they “unlock” the receptors CB1 and CB2, creating a variety of effects.

There are numerous types of endocannabinoids and endocannabinoid receptors, all of which have multiple impacts on the cells. Therefore, it can be incredibly difficult to generalize about their effects. However, this multi-purpose functionality helps to explain why the endocannabinoid system is believed to have an influence on many different diseases and health conditions.

How Are Omega-3s Connected to the Endocannabinoid System?

As mentioned above, endocannabinoids are lipids made from the cells’ omega-3 and omega-6 content. Once cells build up a sufficient inventory of these fatty acids, endocannabinoids are created rapidly and as-needed in response to brain activity and stimuli (like stress and exercise).

Omega-3s are directly involved in the synthesis of endocannabinoids, and also react with existing endocannabinoids to create omega-3-derived endocannabinoid epoxides (which have powerful anti-inflammatory properties)(4). Due to the important role that omega-3s have in the cell membrane, researchers believe that omega-3s also serve as crucial anchors for endocannabinoid cell membrane receptors (5).

To put it simply, omega-3s and endocannabinoids are totally dependent on each other in a healthy brain and body. This connection can also help explain why the noted anxiety and pain relieving effects from taking CBD oil are similar to the results achieved from receiving adequate omega-3 supplementation over time (6).

What Happens When You Don’t Get Enough Omega-3s?

Omega-3 deficiency is widespread in today’s world, impacting some 95% of adults in the United States (7). As researchers have demonstrated, this deficiency has serious consequences for the healthy functioning of our endocannabinoid systems.

Omega-3-deficient diets don’t just limit the creation of beneficial endocannabinoids and the omega-3-derived endocannabinoid epoxides. Studies have also shown that omega-3-deficiency creates dysfunctional endocannabinoid receptors, uncoupling them from the protein and altering signaling pathways in the brain (8).

Health Consequences of Omega-3 Deficiency

Consequences of dysfunctional endocannabinoid receptors (due to omega-3 deficiency) include increased anxiety and impaired behavior, according to one mice study from the University of Bordeaux (9). In addition, studies also show that omega-3 deficiency plays a role in increasing the development of obesity through the dysregulation of the endocannabinoid system (10).

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Chronic deficiency of omega-3s in our diet may partly explain society’s enormous craving for CBD products. What’s more, it may also help to explain the widely-diverse experiences that CBD users have. After all, if one person’s endocannabinoid receptors are dysfunctional, throwing lots of cannabinoids at them won’t necessarily produce the results users are hoping to achieve.

While more research is needed to address these important topics, the above studies raise pressing questions.

Most people in the United States do not get enough omega-3s, either from diet or supplements. This is in stark contrast with other countries, like Japan, where omega-3 intakes are much higher.

Why Do People Prefer CBD to Omega-3 Supplements?

Considering the deep involvement of omega-3s in the endocannabinoid system, you would think that anyone fascinated by CBD’s effects would also have a dual interest in fish oil. However, when compared to most omega-3 supplements, CBD has clear advantages.

While CBD’s effects appear quickly, omega-3s take longer to work – often many weeks of consistent consumption. These rapid effects probably explain why CBD is creating such a buzz. With CBD products, people are also willing to take an adequate dose, but that often isn’t the case with omega-3 products.

CBD, however, does not solve the underlying omega-3 deficiency problem.

Many people have asked us if we make any products with CBD oil in them, but as of the time of publication, we do not. Please also note that the FDA has made it clear that combining CBD into existing supplements is currently not allowed.

Is CBD a Panacea?

Some years ago, I attended a meeting on the effects of a new molecule that had potential for treating Alzheimer’s. The presentation was inspiring, and left attendees with a feeling that this new molecule could be a major therapeutic tool.

Afterwards, I had the chance to discuss the science with the presenter one-on-one.

“Do you believe that a single molecule will do the whole trick in curing or preventing this disease,” I asked.

“Of course not,” he answered. “But the investors may believe it.”

Most physiologists and biologists know that single molecules are rarely a cure-all for complex health issues. Unfortunately, this point often gets missed when we get too focused on isolated substances — either because of the pharmaceutical industry’s desire for patentable products or the appeal of easily understandable buzzwords. The human body and cell metabolism are extremely complex and dependent upon the interactions of a multitude of factors (e.g. genes, environment, nutrition, microbiome, age, gender, etc). Therefore, it’s highly unlikely that changing just one factor will solve chronic conditions for most people.

There isn’t a single substance – whether that’s CBD or even omega-3s – that will ever give us a one-way ticket to good health. But when we understand the underlying mechanisms of the body and employ a synergy of wholesome efforts, we’ll be able to carve a better path forward.

This is the philosophy that guides us at Omega3 Innovations. It’s the reason we’ve created a full-spectrum oil, and the reason we’re passionate about the combination of our Omega Cure oil with melatonin and vitamin D3. It’s why we care about not just increasing our consumption of omega-3s, but also decreasing our intake of omega-6s, and why we like to share advice about how to improve sleep hygiene.

Combination therapy, in our book, is where the biggest medical innovation will come from in the future, and we’re excited to be exploring these principles as a company.

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